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The bias in SpO2 between the smartwatch and the oximeter was 0.0% for all the data points. There were 642 individual pairs of SpO2 measurements. Measurements of SpO2 were taken from the smartwatch and the pulse oximeter simultaneously in 30-s intervals. In the final stabilization phase, the participants inhaled the ambient air again until SpO2 returned to normal values. Then in the 5-minute desaturation phase, the participants breathed the oxygen-reduced gas mixture (12% O2), which temporarily reduced their blood oxygen saturation. First, in the 2-minute initial stabilization phase, the participants inhaled the ambient air. The participants breathed via a breathing circuit with a three-way non-rebreathing valve in three phases. Each participant wore a smartwatch (Apple Watch Series 6) on the left wrist and a pulse oximeter sensor (Masimo Radical-7) on the left middle finger. We investigated how a commercially available smartwatch that measures peripheral blood oxygen saturation (SpO2) can detect hypoxemia compared to a medical-grade pulse oximeter.
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